Bacterial resistance to antimicrobials is recognised by the WHO as a major health threat of the 21st century and as the third largest threat to humanity. Antimicrobial Stewardship (AS) promotes rational use of antimicrobials as a way to control the spread of antimicrobial resistance. Our aim is to build a decision support module for AS by targeting its application at point-of-care. We will develop, integrate, test and implement an optimized version of the decision support module (DSM) TREAT, to improve individualized infectious disease diagnosis, rational treatment and management of ongoing therapy in the hospital setting. The outcome of the project involving partners in Denmark, Sweden and Israel is a fully integrated DSM ready for implementation in other centres allowing for a personalized medicine approach, lowering the total usage of prescribed antimicrobials, while prescribing appropriate therapy to those who need it.