TIPS is a project on personalised medicine for improved understanding and management of paediatric severe inflammatory response syndrome (SIRS). SIRS, which can affect children without predisposing factors is a life-threatening event due to an uncontrolled activation of the immune system as a results of, often, unknown triggers. For the majority of patients, acute management of SIRS is based on clinical features and routine laboratory parameters without distinct stratification, demonstrating the need for better and precise diagnostics. We aim to generate personalised immune profiling and to identify diagnostic patterns in order to develop individualized therapies to improve patient outcome. In this transnational endeavour, we will integrate consideration of ethico-legal aspects of patient safety and data protection.