Prevalence of twin pregnancies is rising globally due to increased assisted conception and advanced maternal age in pregnancy. Twins have 5-9 higher prevalence of major pregnancy complications such as prematurity, low birth weight, pregnancy hypertension and  diabetes. They also have special syndromes of identical twins. Consequently, more twins are born prematurely, suffer from low birth weight, cerebral palsy, etc., often requiring admission to newborn intensive care units, and develop motor and cognitive disorders for life. These impose a huge burden on individuals, families, and the society. Our group will special methods for prediction and prevention of pregnancy complications in twins, and conduct modelling with our large study size. With multiple measured we will  yield a comprehensive way for identifying twin risks, offering personalized, preventive clinical care of their disorders. This would enable a paradigm shift in prenatal personalized care for twin pregnancy.