So far, we have infrequently been able to cure late stage cancers with medical treatments. Late stage cancers acquire multiple drug resistance mechanisms and thus a combination of drugs may be needed for treatment, making the discovery of a cure for late stage disease extremely challenging. Integration of multiple molecular data with patients’ clinical history is today crucial to apprehend new mechanisms related to drug efficacy or resistance. Via the PEVO^data project, with its core the PEVO^SQ basket trial in patients with late stage squamous cell carcinomas treated with pembrolizumab in combination with vorinostat, we aim to: 1) explore the modifications of immune-related and molecular-epigenetic biomarkers; 2) build a database integrating molecular and clinical profiles for treatment decision;  3) develop long-term standards alongside other strategies for data collection and management, and 4) set a module for patients inclusion in clinical trials.