Diagnosis of disorders of consciousness (DoC) patients cannot be misleading, as it guides critical decisions. Despite this importance current behavioral diagnosis often fails, in most cases due to the patients’ major sensory and motor deficits. The need for accurate diagnosis and prognosis transcends patients: caregiving in DoC is very stressful, principally for the large uncertainty associated with them. The PerBrain Project will combine the multidisciplinary partners’ expertise, and multisite and multimodal assessments of patients. Based on the collected data we will use state-of-the-art computational tools to develop a multimodal personalized diagnostic and prognostic tool for DoC patients. The overall aim of this project is to pave the way towards a better understanding of the pathophysiological mechanisms in DoC, which will, in turn, allow personalized rehabilitation strategies, and improved single-patient predictions of clinical state and prognosis.