The COMPASS-PM course is a 4-week, 20-hour online module designed to introduce general practitioners (GPs) to personalised medicine (PM). It covers foundational PM concepts, molecular diagnostics, clinical applications in cardiometabolic care, and strategies for integration into primary care. The module uses case-based learning, reflective writing, and interactive assessments to support practical application. Its main objectives are to improve GPs’ understanding of PM, enhance decision-making, and foster ethical, patient-centred care. The target audience is GPs at all career stages, with prior experience in managing chronic conditions. The course aims to bridge knowledge gaps and support sustainable PM implementation in European healthcare.