Heart failure is a major medical problem for which 1–2% of the health care budget is spent worldwide. It affects especially elderly, with 80% hospitalizations occurring among patients above 65 years. In addition, 70% of these patients are readmitted to hospital within one year, making re-hospitalization an ongoing medical challenge. In this context, the PerHeart project is employing Information and Communication Technology with the main goal of reducing re-hospitalization rates in heart failure patients by: supporting disease self-management; providing real-time personalized feedback for patients and their caregivers; elucidating specific risk factors for readmission; providing data that can help interpretation and prediction of complex multifactorial diseases. Transnational collaboration between multidisciplinary teams from the five countries, combined with previous experience in developing ambient assistive living solutions, will ensure a successful implementation of the project.