E-SCOPE brings together key stakeholders in personalised medicine (PM) to strengthen the translation of Ethical, Legal and Social Issues (ELSI) research into clinical practice, building on the strong foundations of ELSI work packages from ERAPerMed projects. Despite significant advances in PM, the impact of ELSI research has been limited by heterogeneous approaches, lack of follow-up, and funding structures that rarely allow engagement both before project start and after its conclusion. Consequently, opportunities to shape research design with stakeholder input and guide implementation into healthcare are frequently missed, and clinical translation of ELSI insights remains underemphasised.

To address these barriers, E-SCOPE will convene a 3 days hybrid Stakeholder Consensus Conference, a methodology connecting clinicians, PM researchers, ethics committee members, patient representatives and organisations, and technology developers.

This networking event builds on work initiated in the KidneySign project, in which a dedicated network of 26 ELSI collaborators across 10 projects funded under the ERA PerMed Joint Transnational Call 2022 (KidneySign, IPerGlio, MG-PerMed, LANTERN, OmegaPerMed, OPTIMA, PARADISE, PERMEPSY, Stracyfic, miRPOC) was created.

The event will focus on four key translational challenges:

1. data governance and data circulation;
2. clinical usability and acceptance of AI tools;
3. meaningful, sustained stakeholder engagement;
4. ensuring equitable access to PM innovations.

Building on prior ERAPerMed results, participants will

1. work together to establish sustainable networks,
2. systematise common challenges,
3. co-develop actionable recommendations to enhance clinical impact.

Outputs will include a jointly authored guideline and a dedicated special issue to secure broad dissemination and uptake. E-SCOPE will create enduring structures for collaboration. The initiative contributes directly to EPPerMed’s vision by ensuring that advances in PM are not only scientifically innovative, but also ethically robust, legally sound, socially responsive, and ready for implementation.